Diabetes breakthrough
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Coming from a family that has inherited both types of diabetes( type 1 and Type 2) In the last twenty or so years ,whenever I see a story about a new discovery that would lead to a cure I get exited. for the world of diabetics as well as myself.
I usually follow the story anxiously with baited breath for a few weeks, dreaming about the possibility that this time there on the right track until the trail gets cold and everyone’s hopes fade away.
Its been the story of most breakthrough’s in Diabetic Cure discoveries in the past twenty years but this one might prove to be the one that succeeds.
Recently scientist at a Toronto hospital have proven that they could trigger diabetic mice to became healthy virtually overnight after being injected with a substance to counteract the effect of malfunctioning pain neurons in the pancreas.
“I couldn’t believe it,” said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. “Mice with diabetes suddenly didn’t have diabetes any more.”
The researchers caution they have yet to confirm their findings in people, but say they expect results from human studies within a year or so. Any treatment that may emerge to help at least some patients would likely be years away from hitting the market.
Unfortunately, for the suffering public, this is always the unacceptable response that accompanies these discoveries. The results are then passed on to pharmaceutical companies where the cure will linger in the corner of a lab and be forgotten forever. It’s not good business for giant pharmaceuticals to invent cures. If a cure works they will effectively have gotten rid of their customer base. It’s better for big Pharma to produce better controls, and they are extremely good at this, better meters, long lasting insulin, ect.. to keep us alive longer so wee can continue to buy their products.
How this research differs from all the heartbreaking failures that came before it is that their conclusions upset conventional wisdom that Type 1 diabetes, the most serious form of the illness that typically first appears in childhood, was solely caused by auto-immune responses — the body’s immune system turning on itself.
They also concluded that there are far more similarities than previously thought between Type 1 and Type 2 diabetes, and that nerves likely play a role in other chronic inflammatory conditions, such as asthma and Crohn’s disease.
Suspecting a link between the nerves and diabetes, Dr. Hans Michael Dosch and Dr. Salter injected capsaicin, the active ingredient in hot chili peppers, to kill the pancreatic sensory nerves in mice that had an equivalent of Type 1 diabetes
So next they injected the neuropeptide “substance P” in the pancreases of diabetic mice, the results were dramatic. The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection.
They also discovered that their treatments curbed the insulin resistance that is the hallmark of Type 2 diabetes, and that insulin resistance is a major factor in Type 1 diabetes, suggesting the two illnesses are quite similar.
Now here comes the heartbreaking part of this story . While some of the pain scientists have been receptive to the research, the doubting Thomas’s immunologists have voiced scepticism at the idea of the nervous system playing such a major role in the disease. Editors of Cell put the Toronto researchers through vigorous review to prove the validity of their conclusions, though an editorial in the publication gives a positive review of the work.
This is usually were you never hear from exiting discoveries again.
“It will no doubt cause a great deal of consternation,” said Dr. Salter about his paper.
The researchers are now setting out to confirm that the connection between sensory nerves and diabetes holds true in humans. If it does, they will see if their treatments have the same effects on people as they did on mice.
Nothing is for sure, but “there is a great deal of promise,” Dr. Salter said
About two million Canadians suffer from diabetes, 10% of them with Type 1, contributing to 41,000 deaths a year. Can you imagine the monetary saving alone if this group of people would have the ability to get a cure? No more costly hospital stays. We could free up thousands of nurses and doctors . This would cut our yearly Medicare cost by billions a year, and this is for just one type of disease.
I’m not much of a conspiracy nut but if this one gets in the hands of a pharamacompanie , would someone let me know the odds that this method will disappear just like all its predecessors, never to be heard of again.
Faces of Diabetes Lets stop the decades old broken promise of a cure and give them the gift of life.
